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AAs had a significantly slower extrinsic aging compared to whites. We assessed three epigenetic age acceleration measures (universal, intrinsic, and extrinsic). AAs had more age-associated DNAm changes than whites in genes implicated in age-related diseases and cellular pathways involved in growth and development. Of these, 75.6% and 53.1% were novel, largely driven by the increased number of measured CpGs in the EPIC array, in AA and whites, respectively. We identified 4930 significantly associated aDMPs in AAs and 469 in whites. We measured genome-wide DNA methylation (866,836 CpGs) using the Illumina MethylationEPIC BeadChip in blood DNA extracted from 487 middle-aged AA ( N = 244) and white ( N = 243), men ( N = 248), and women ( N = 239). Since DNAm has not been widely studied among non-European populations, we examined the association between DNAm and chronological age in AAs and whites, and the association between race, poverty, sex, and epigenetic age acceleration. DNA methylation (DNAm) levels at specific CpG positions are hallmarks of aging evidenced by the presence of age-associated differentially methylated CpG positions (aDMPs) that are the basis for the epigenetic clock for measuring biological age acceleration. African Americans (AAs) experience premature chronic health outcomes and longevity disparities consistent with an accelerated aging phenotype.